DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_1

Location: 3632:3638

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 82.9143

COIL: 0.9686

CONS_SCORE: 0.3766

DSS_SCORE: 0.8033

HELIX: 0.0124

FCONS_SCORE: 1.0716

RIG_SCORE: 0.542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3634P	TCGA-44-8120	LUAD	TCGA	PPTPGIS	DEG_SCF_FBW7_1	0.7031
p.T3634P	DO45402	LUAD	ICGC	PPTPGIS	DEG_SCF_FBW7_1	0.7031
p.P3633Q	TCGA-44-8120	LUAD	TCGA	PPTPGIS	DEG_SCF_FBW7_1	0.5924
p.P3633Q	DO45402	LUAD	ICGC	PPTPGIS	DEG_SCF_FBW7_1	0.5924
p.E3639V	TCGA-A5-A2K5	UCEC	TCGA	PPTPGIS	DEG_SCF_FBW7_1	0.3056
p.E3639V	DO41379	UCEC	ICGC	PPTPGIS	DEG_SCF_FBW7_1	0.3056
p.S3642C	TCGA-CV-5444	HNSC	TCGA	PPTPGIS	DEG_SCF_FBW7_1	0.2222
p.S3642C	DO14598	HNSC	ICGC	PPTPGIS	DEG_SCF_FBW7_1	0.2222
p.D3628N	TCGA-IG-A3Y9	ESCA	TCGA	PPTPGIS	DEG_SCF_FBW7_1	0.2222
p.T3648K	DO228986	LICA	ICGC	PPTPGIS	DEG_SCF_FBW7_1	0.0556
p.P3644S	SIDM01098	Neuroblastoma	GDSC	PPTPGIS	DEG_SCF_FBW7_1	0.1667
p.P3644S	SK-N-SH	autonomic_ganglia	COSMIC	PPTPGIS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	3632:3638	PPTPGIS	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons