DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPTPGIS
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
DEG_SCF_FBW7_1
Location:
3632:3638
E3 ligase:
FBXW7
DEGRON score:
0.9927
ASA_SCORE:
82.9143
COIL:
0.9686
CONS_SCORE:
0.3766
DSS_SCORE:
0.8033
HELIX:
0.0124
FCONS_SCORE:
1.0716
RIG_SCORE:
0.542
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T3634P
TCGA-44-8120
LUAD
TCGA
PPTPGIS
DEG_SCF_FBW7_1
0.7031
p.T3634P
DO45402
LUAD
ICGC
PPTPGIS
DEG_SCF_FBW7_1
0.7031
p.P3633Q
TCGA-44-8120
LUAD
TCGA
PPTPGIS
DEG_SCF_FBW7_1
0.5924
p.P3633Q
DO45402
LUAD
ICGC
PPTPGIS
DEG_SCF_FBW7_1
0.5924
p.E3639V
TCGA-A5-A2K5
UCEC
TCGA
PPTPGIS
DEG_SCF_FBW7_1
0.3056
p.E3639V
DO41379
UCEC
ICGC
PPTPGIS
DEG_SCF_FBW7_1
0.3056
p.S3642C
TCGA-CV-5444
HNSC
TCGA
PPTPGIS
DEG_SCF_FBW7_1
0.2222
p.S3642C
DO14598
HNSC
ICGC
PPTPGIS
DEG_SCF_FBW7_1
0.2222
p.D3628N
TCGA-IG-A3Y9
ESCA
TCGA
PPTPGIS
DEG_SCF_FBW7_1
0.2222
p.P3644S
SIDM01098
Neuroblastoma
GDSC
PPTPGIS
DEG_SCF_FBW7_1
0.1667
p.P3644S
SK-N-SH
autonomic_ganglia
COSMIC
PPTPGIS
DEG_SCF_FBW7_1
0.1667
p.T3648K
DO228986
LICA
ICGC
PPTPGIS
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with KMT2C mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPTPGIS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_SCF_FBW7_1
3632:3638
PPTPGIS
FBXW7
0.9927
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