DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SPOP_SBC_1

Location: 223:227

E3 ligase: SPOP

DEGRON score: 0.6126

ASA_SCORE: 70.22

COIL: 0.8014

CONS_SCORE: 0.2146

DSS_SCORE: 0.5431

HELIX: 0.1304

FCONS_SCORE: 0.8462

RIG_SCORE: 0.7741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R234Q	TCGA-06-5858	GBM	TCGA	ACTST	DEG_SPOP_SBC_1	0.1389
p.R234Q	DO10892	GBM	ICGC	ACTST	DEG_SPOP_SBC_1	0.1389
p.R230Q	TCGA-AP-A1DK	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	0.25
p.R230Q	DO42033	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	0.25
p.G221V	TCGA-D8-A1X5	BRCA	TCGA	ACTST	DEG_SPOP_SBC_1	0.2778
p.G221V	DO3590	BRCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.P233Q	DO229026	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1667
p.T232K	DO229008	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1944
p.R229C	DO228138	PBCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.R229C	ACH-000143	Lung Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	0.2778
p.A237P	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.0556
p.A237P	ACH-002272	Lymphoma	CCLE	ACTST	DEG_SPOP_SBC_1	0.0556
p.A237P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	0.0556
p.D218E	SIDM00845	Burkitt's Lymphoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.1944
p.D218E	ACH-000786	Lymphoma	CCLE	ACTST	DEG_SPOP_SBC_1	0.1944
p.D218E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	0.1944
p.D218E	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	0.1944
p.T225P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	0.7031
p.T225P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14534	Squalene monooxygenase	DEG_SPOP_SBC_1	114:118	ACTST	SPOP	0.963	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	810:814	ACTST	SPOP	0.9874	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	1658:1662	ACTST	SPOP	0.8141	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	223:227	ACTST	SPOP	0.6126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons