DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SCF_FBW7_1

Location: 1490:1497

E3 ligase: FBXW7

DEGRON score: 0.6603

ASA_SCORE: 96.2375

COIL: 0.8931

CONS_SCORE: 0.249

DSS_SCORE: 0.3317

HELIX: 0.0181

FCONS_SCORE: 0.9148

RIG_SCORE: 0.7684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1503T	TCGA-B5-A11J	UCEC	TCGA	INMTPALT	DEG_SCF_FBW7_1	0.1667
p.A1495V	TCGA-B5-A1MR	UCEC	TCGA	INMTPALT	DEG_SCF_FBW7_1	0.5825
p.L1501I	DO225334	BRCA	ICGC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.T1487A	DO10020	COAD	ICGC	INMTPALT	DEG_SCF_FBW7_1	0.25
p.P1484S	DO222843	MELA	ICGC	INMTPALT	DEG_SCF_FBW7_1	0.1667
p.A1494T	DO232224	PBCA	ICGC	INMTPALT	DEG_SCF_FBW7_1	0.7139
p.P1490T	DO37738	SKCM	ICGC	INMTPALT	DEG_SCF_FBW7_1	0.7031
p.N1486S	SIDM01020	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00535	Chondrosarcoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00362	Burkitt's Lymphoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00465	Ovarian Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00457	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00260	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00612	Glioma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00616	Hepatocellular Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00591	Oral Cavity Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01551	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01660	Kidney Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01472	Hepatocellular Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM00248	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01575	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01413	Oral Cavity Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.N1486S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	0.2222
p.P1482T	IGROV-1	ovary	COSMIC	INMTPALT	DEG_SCF_FBW7_1	0.1111
p.P1503L	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	INMTPALT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INMTPALT

Degron related mutations and impact score

Drug responses associated with KIAA2026 mutations

All proteins holding degron of INMTPALT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SCF_FBW7_1	1490:1497	INMTPALT	FBXW7	0.6603	More...