DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_SCF_FBW7_1

Location: 966:973

E3 ligase: FBXW7

DEGRON score: 0.9561

ASA_SCORE: 96.425

COIL: 0.9764

CONS_SCORE: 0.3119

DSS_SCORE: 0.6684

HELIX: 0.0076

FCONS_SCORE: 1.0115

RIG_SCORE: 0.5789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P978Q	TCGA-D3-A2JP	SKCM	TCGA	PNITPSSS	DEG_SCF_FBW7_1	0.1944
p.P966L	DO233731	GACA	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.6471
p.D958V	DO12076	GBM	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.1111
p.N969S	DO52095	HNSC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.7069
p.D958H	DO231747	LINC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.1111
p.S961R	DO40879	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.1944
p.G979C	DO223286	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.1667
p.S961I	DO43041	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	0.1944
p.G957D	ACH-001063	Ovarian Cancer	CCLE	PNITPSSS	DEG_SCF_FBW7_1	0.0833
p.P970L	ACH-001550	Skin Cancer	CCLE	PNITPSSS	DEG_SCF_FBW7_1	0.7582
p.P982Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PNITPSSS	DEG_SCF_FBW7_1	0.0833
p.P982Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PNITPSSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SCF_FBW7_1	966:973	PNITPSSS	FBXW7	0.9561	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons