DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_SCF_TRCP1_1

Location: 1488:1494

E3 ligase: BTRC

DEGRON score: 0.5711

ASA_SCORE: 87.3857

COIL: 0.8961

CONS_SCORE: 0.2908

DSS_SCORE: 0.5509

HELIX: 0.0191

FCONS_SCORE: 1.0508

RIG_SCORE: 0.6225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1493I	TCGA-29-1693	OV	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.5965
p.V1493I	TCGA-98-8021	LUSC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.5965
p.D1488N	TCGA-AP-A1DV	UCEC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.6932
p.D1488N	TCGA-DU-6392	LGG	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.6932
p.S1501F	TCGA-DD-AACD	LIHC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.1389
p.S1496F	TCGA-FW-A3R5	SKCM	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	0.7222
p.A1498T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	0.2222
p.A1498T	SIDM00954	Breast Carcinoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	0.2222
p.A1498T	SIDM01173	Rhabdomyosarcoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	0.2222
p.R1504W	SIDM01525	Acute Myeloid Leukemia	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	0.0556
p.V1503I	ACH-000185	Non-Cancerous	CCLE	DSGSKVS	DEG_SCF_TRCP1_1	0.0833
p.S1491L	ACH-001982	Metastasis	CCLE	DSGSKVS	DEG_SCF_TRCP1_1	0.6556
p.Y1502H	CCK-81	large_intestine	COSMIC	DSGSKVS	DEG_SCF_TRCP1_1	0.1111
p.W1487R	HCC1569	breast	COSMIC	DSGSKVS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SCF_TRCP1_1	1488:1494	DSGSKVS	BTRC	0.5711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons