DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_MDM2_SWIB_1

Location: 233:241

E3 ligase: MDM2

DEGRON score: 0.5732

ASA_SCORE: 51.7556

COIL: 0.1794

CONS_SCORE: 0.4973

DSS_SCORE: 0.1837

HELIX: 0.8059

FCONS_SCORE: 1.3298

RIG_SCORE: 0.9385

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R247H	TCGA-25-1319	OV	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1667
p.S251Y	TCGA-66-2789	LUSC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.0556
p.S251Y	DO27279	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.0556
p.D232Y	TCGA-A5-A1OF	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.3056
p.D232Y	DO42568	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.3056
p.R247S	TCGA-B5-A0JY	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1667
p.F236L	TCGA-B5-A1MR	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.587
p.F236L	DO41758	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.587
p.D239V	TCGA-BR-4370	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.6674
p.D239V	DO38499	STAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.6674
p.V241I	TCGA-CD-A4MG	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.5965
p.V241I	DO48009	STAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.5965
p.R247C	TCGA-EO-A22R	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1667
p.R247C	TCGA-R5-A7ZI	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1667
p.T229S	TCGA-SS-A7HO	COAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	0.2222
p.T229S	DO223705	COAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.2222
p.D239H	DO480	BLCA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.6577
p.R233L	DO229027	LICA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.8428
p.R233L	DO27755	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.8428
p.V227F	DO229032	LICA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1667
p.W250L	DO23742	LUAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.0833
p.A243S	DO45527	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.2778
p.S236F	DO45513	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.7982
p.S236F	DO222494	MELA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.7982
p.R233C	DO222644	MELA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.8301
p.R233C	DO41020	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.8301
p.R233C	DO41488	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.8301
p.D239N	SIDM00216	Colorectal Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.5821
p.D239N	ACH-000989	Colon/Colorectal Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	0.5821
p.D248G	SIDM00710	Small Cell Lung Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1389
p.D248G	ACH-000394	Lung Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1389
p.D248G	NCI-H2081	lung	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.1389
p.D230Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.25
p.D230Y	ACH-000951	Lung Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	0.25
p.D230Y	NCI-H2342	lung	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.25
p.W244R	HCC1569	breast	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.25
p.P244A	CHP-134	autonomic_ganglia	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FVKFWKDIV

Degron related mutations and impact score

Drug responses associated with ARID2 mutations

All proteins holding degron of FVKFWKDIV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_MDM2_SWIB_1	233:241	FVKFWKDIV	MDM2	0.5732	More...