DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_SPOP_SBC_1

Location: 1471:1475

E3 ligase: SPOP

DEGRON score: 0.961

ASA_SCORE: 98.86

COIL: 0.9222

CONS_SCORE: 0.2045

DSS_SCORE: 0.5575

HELIX: 0.0192

FCONS_SCORE: 0.7824

RIG_SCORE: 0.6791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1464H	TCGA-34-2596	LUSC	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1389
p.R1464H	TCGA-VQ-A91D	STAD	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1389
p.S1470L	TCGA-B5-A1MW	UCEC	TCGA	PHSTT	DEG_SPOP_SBC_1	0.75
p.R1464C	TCGA-BR-4292	STAD	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1389
p.R1464C	SIDM00253	Neuroblastoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.1389
p.R1464C	NB6	autonomic_ganglia	COSMIC	PHSTT	DEG_SPOP_SBC_1	0.1389
p.S1466I	TCGA-HG-A9SC	CESC	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1944
p.T1475A	SIDM00845	Burkitt's Lymphoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.7139
p.S1476P	SIDM00845	Burkitt's Lymphoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.P1461L	SIDM01175	Other Sarcomas	GDSC	PHSTT	DEG_SPOP_SBC_1	0.0556
p.P1461L	ACH-002309	Sarcoma	CCLE	PHSTT	DEG_SPOP_SBC_1	0.0556
p.P1461L	SW684	soft_tissue	COSMIC	PHSTT	DEG_SPOP_SBC_1	0.0556
p.R1464P	SIDM00245	Small Cell Lung Carcinoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.1389
p.R1464P	MS-1	lung	COSMIC	PHSTT	DEG_SPOP_SBC_1	0.1389
p.T1474A	SIDM01619	Endometrial Carcinoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.7139
p.T1474A	ACH-000984	Endometrial/Uterine Cancer	CCLE	PHSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1095:1099	PHSTT	SPOP	0.6709	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	1471:1475	PHSTT	SPOP	0.961	More...
Q8NFZ4	Neuroligin-2	DEG_SPOP_SBC_1	829:833	PHSTT	SPOP	0.9949	More...
Q5SQH8	Uncharacterized protein C6orf136	DEG_SPOP_SBC_1	39:43	PHSTT	SPOP	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons