DegronMD

Uniprot ID: Q96LA8

Source protein: Protein arginine N-methyltransferase 6

Source gene: PRMT6

Class: DEG_SPOP_SBC_1

Location: 306:310

E3 ligase: SPOP

DEGRON score: 0.5624

ASA_SCORE: 23.4

COIL: 0.4472

CONS_SCORE: 0.7473

DSS_SCORE: 0.41

HELIX: 0.0116

FCONS_SCORE: 1.3535

RIG_SCORE: 0.7333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S310L	TCGA-60-2720	LUSC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.7667
p.S310L	DO26587	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7667
p.P314S	TCGA-AR-A0U2	BRCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2222
p.P314S	DO5067	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2222
p.G299V	TCGA-ER-A195	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1389
p.G299V	DO47712	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.G298R	TCGA-QC-A7B5	SARC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1111
p.G298R	DO220239	SARC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.Q320R	DO233109	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.T309P	DO46366	OV	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7031
p.A315V	SIDM00001	Other Blood Cancers	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.A315V	ACH-000405	Leukemia	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1944
p.F296L	SIDM00313	Hodgkin's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.F296L	ACH-000702	Lymphoma	CCLE	VLSTS	DEG_SPOP_SBC_1	0.0556
p.F296L	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.E302V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	0.2222
p.E302V	ACH-000920	Leukemia	CCLE	VLSTS	DEG_SPOP_SBC_1	0.2222
p.E302V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons