DegronMD - Q32MK0(MYLK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P187S	TCGA-B5-A3FA	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.0833
p.P187S	DO52402	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.0833
p.G169E	TCGA-BH-A0EB	BRCA	TCGA	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1944
p.G169E	DO1284	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1944
p.P171L	TCGA-D3-A3C7	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.25
p.P171L	DO47569	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.25
p.S176N	TCGA-EO-A22R	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.7069
p.S176N	DO42713	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.7069
p.E186K	TCGA-GV-A3QH	BLCA	TCGA	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1111
p.E186K	DO464	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1111
p.S169C	DO856	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1944
p.A184D	DO229015	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.E178K	DO222731	MELA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.7022
p.L175Q	DO48944	PBCA	ICGC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.6654
p.E186Q	SIDM00704	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1111
p.E186Q	ACH-000639	Lung Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1111
p.E186Q	NCI-H211	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1111
p.R184Q	ACH-000599	Pancreatic Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.R184Q	PA-TU-8902	pancreas	COSMIC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.G183C	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1944

Kaplan plot for MYLK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYLK3

UniProt ID: Q32MK0

Entrez ID: 91807

Protein name: Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYLK3 in