DegronMD - Q8TEJ3(SH3RF3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G346S	TCGA-06-6693	GBM	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.6993
p.G346S	DO11968	GBM	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.6993
p.C707Y	TCGA-29-1702	OV	TCGA	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1389
p.C707Y	DO29528	OV	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1389
p.N704T	TCGA-2H-A9GO	ESCA	TCGA	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.2222
p.S613F	TCGA-AA-3967	COAD	TCGA	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1389
p.S613F	DO10124	COAD	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1389
p.D710E	TCGA-AD-6895	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.0556
p.D710E	DO8938	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.0556
p.R620Q	TCGA-AG-A02N	READ	TCGA	RPTATVSPL	DEG_SIAH_1	620:628	Mutation altering degron motif	0.6218
p.R620Q	DO37146	READ	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation altering degron motif	0.6218
p.P342S	TCGA-AP-A1DV	UCEC	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.P342S	DO43186	UCEC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.N632Y	TCGA-AX-A06F	UCEC	TCGA	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2222
p.N632Y	DO41752	UCEC	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2222
p.A689P	TCGA-CA-6717	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1389
p.A689P	DO8264	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1389
p.L341R	TCGA-CX-7082	HNSC	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.L341R	DO14268	HNSC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.N704S	TCGA-EO-A3B0	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.2222
p.N704S	DO219773	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.2222
p.R629C	TCGA-F4-6570	COAD	TCGA	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.3056
p.R629C	DO10443	COAD	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.3056
p.R629H	TCGA-IB-7651	PAAD	TCGA	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.3056
p.R629H	DO222764	ESCA	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.3056
p.R629H	DO46657	PAAD	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.3056
p.L697P	DO225106	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.6471
p.S698A	DO225106	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7588
p.V351M	DO50329	ESAD	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.3056
p.S354R	DO228627	GACA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2222
p.I694V	DO233168	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.2778
p.A339S	DO229015	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1944
p.G695C	DO229015	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.3056
p.V351L	DO229022	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.3056
p.S701I	DO229024	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.3056
p.A352T	DO50970	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.A339V	DO224563	LUSC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1944
p.R636C	DO229123	NKTL	ICGC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1111
p.S698F	DO228011	SKCA	ICGC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S359I	SIDM02071	Esophageal Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.0833
p.S700F	SIDM00985	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01109	Other Sarcomas	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01248	Thyroid Gland Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM00190	Melanoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM00091	Ovarian Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM00710	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM00943	Pancreatic Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01715	Non-Cancerous	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01323	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01765	Osteosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.S700F	SIDM01167	Thyroid Gland Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation altering degron motif	0.7982
p.P353S	SIDM00321	Ovarian Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	SIDM00561	Other Blood Cancers	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	SIDM00243	Other Solid Cancers	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	ACH-000430	Ovarian Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	ACH-002062	Lymphoma	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	ACH-002274	Leukemia	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	ACH-002288	Embryonal Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	MLMA	haematopoietic and lymphoid tissue	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	SLVL	haematopoietic and lymphoid tissue	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	NEC8	testis	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.P353S	TYK-nu	ovary	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25
p.Q618E	SIDM00108	Melanoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00632	Non-Cancerous	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00731	Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM01165	Pancreatic Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00965	Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00963	Breast Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00964	Non-Cancerous	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00105	Ovarian Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00937	Oral Cavity Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM01624	Bladder Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM01529	Bladder Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.Q618E	SIDM00093	Ovarian Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.2778
p.G706V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1667
p.G706V	SIDM00793	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1667
p.R636H	SIDM00986	Head and Neck Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1111
p.R636H	ACH-000548	Head and Neck Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1111
p.R636H	BHY	upper aerodigestive tract	COSMIC	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1111
p.T705M	SIDM01322	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1944
p.S350N	SIDM01608	Endometrial Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.7069
p.S350N	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.7069
p.S635P	ACH-000966	Ovarian Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1389
p.S635P	ACH-001591	Lung Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1389
p.P693S	ACH-001853	Bile Duct Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.25
p.S635F	ACH-001982	Metastasis	CCLE	RPTATVSPL	DEG_SIAH_1	620:628	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3RF3

UniProt ID: Q8TEJ3

Entrez ID: 344558

Protein name: E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3RF3 in