DegronMD

Uniprot ID: Q8TEJ3

Source protein: E3 ubiquitin-protein ligase SH3RF3

Source gene: SH3RF3

Class: DEG_SCF_TRCP1_1

Location: 344:350

E3 ligase: BTRC

DEGRON score: 0.9253

ASA_SCORE: 75.1857

COIL: 0.8397

CONS_SCORE: 0.3142

DSS_SCORE: 0.4195

HELIX: 0.1173

FCONS_SCORE: 0.9202

RIG_SCORE: 0.6342

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G346S	TCGA-06-6693	GBM	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	0.6993
p.G346S	DO11968	GBM	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.6993
p.P342S	TCGA-AP-A1DV	UCEC	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	0.2778
p.P342S	DO43186	UCEC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.2778
p.L341R	TCGA-CX-7082	HNSC	TCGA	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.L341R	DO14268	HNSC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.V351M	DO50329	ESAD	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.3056
p.S354R	DO228627	GACA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.2222
p.A339S	DO229015	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.1944
p.V351L	DO229022	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.3056
p.A352T	DO50970	LICA	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.2778
p.A339V	DO224563	LUSC	ICGC	DSGAVAS	DEG_SCF_TRCP1_1	0.1944
p.S359I	SIDM02071	Esophageal Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.0833
p.P353S	SIDM00321	Ovarian Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	SIDM00561	Other Blood Cancers	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	SIDM00243	Other Solid Cancers	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	ACH-000430	Ovarian Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	ACH-002062	Lymphoma	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	ACH-002274	Leukemia	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	ACH-002288	Embryonal Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	NEC8	testis	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.P353S	TYK-nu	ovary	COSMIC	DSGAVAS	DEG_SCF_TRCP1_1	0.25
p.S350N	SIDM01608	Endometrial Carcinoma	GDSC	DSGAVAS	DEG_SCF_TRCP1_1	0.7069
p.S350N	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGAVAS	DEG_SCF_TRCP1_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGAVAS

Degron related mutations and impact score

Drug responses associated with SH3RF3 mutations

All proteins holding degron of DSGAVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SCF_TRCP1_1	344:350	DSGAVAS	BTRC	0.9253	More...