DegronMD

Uniprot ID: Q8TEJ3

Source protein: E3 ubiquitin-protein ligase SH3RF3

Source gene: SH3RF3

Class: DEG_SIAH_1

Location: 620:628

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9843

ASA_SCORE: 66.7444

COIL: 0.8519

CONS_SCORE: 0.4123

DSS_SCORE: 0.7318

HELIX: 0.0697

FCONS_SCORE: 1.0884

RIG_SCORE: 0.6623

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S613F	TCGA-AA-3967	COAD	TCGA	RPTATVSPL	DEG_SIAH_1	0.1389
p.S613F	DO10124	COAD	ICGC	RPTATVSPL	DEG_SIAH_1	0.1389
p.R620Q	TCGA-AG-A02N	READ	TCGA	RPTATVSPL	DEG_SIAH_1	0.6218
p.R620Q	DO37146	READ	ICGC	RPTATVSPL	DEG_SIAH_1	0.6218
p.N632Y	TCGA-AX-A06F	UCEC	TCGA	RPTATVSPL	DEG_SIAH_1	0.2222
p.N632Y	DO41752	UCEC	ICGC	RPTATVSPL	DEG_SIAH_1	0.2222
p.R629C	TCGA-F4-6570	COAD	TCGA	RPTATVSPL	DEG_SIAH_1	0.3056
p.R629C	DO10443	COAD	ICGC	RPTATVSPL	DEG_SIAH_1	0.3056
p.R629H	TCGA-IB-7651	PAAD	TCGA	RPTATVSPL	DEG_SIAH_1	0.3056
p.R629H	DO222764	ESCA	ICGC	RPTATVSPL	DEG_SIAH_1	0.3056
p.R629H	DO46657	PAAD	ICGC	RPTATVSPL	DEG_SIAH_1	0.3056
p.R636C	DO229123	NKTL	ICGC	RPTATVSPL	DEG_SIAH_1	0.1111
p.Q618E	SIDM00108	Melanoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00632	Non-Cancerous	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00731	Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM01165	Pancreatic Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00965	Small Cell Lung Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00963	Breast Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00964	Non-Cancerous	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00105	Ovarian Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00937	Oral Cavity Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM01624	Bladder Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM01529	Bladder Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.Q618E	SIDM00093	Ovarian Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.2778
p.R636H	SIDM00986	Head and Neck Carcinoma	GDSC	RPTATVSPL	DEG_SIAH_1	0.1111
p.R636H	ACH-000548	Head and Neck Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	0.1111
p.R636H	BHY	upper_aerodigestive_tract	COSMIC	RPTATVSPL	DEG_SIAH_1	0.1111
p.S635P	ACH-000966	Ovarian Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	0.1389
p.S635P	ACH-001591	Lung Cancer	CCLE	RPTATVSPL	DEG_SIAH_1	0.1389
p.S635F	ACH-001982	Metastasis	CCLE	RPTATVSPL	DEG_SIAH_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RPTATVSPL

Degron related mutations and impact score

Drug responses associated with SH3RF3 mutations

All proteins holding degron of RPTATVSPL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SIAH_1	620:628	RPTATVSPL	SIAH1,SIAH2,SIAH3	0.9843	More...