DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_COP1_1

Location: 862:869

E3 ligase: COP1

DEGRON score: 0.9963

ASA_SCORE: 78.6875

COIL: 0.8635

CONS_SCORE: 0.2829

DSS_SCORE: 0.3605

HELIX: 0.0708

FCONS_SCORE: 1.0422

RIG_SCORE: 0.7427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P861S	TCGA-39-5028	LUSC	TCGA	SEVKVPEF	DEG_COP1_1	0.3056
p.Q859H	TCGA-44-7659	LUAD	TCGA	SEVKVPEF	DEG_COP1_1	0.25
p.P861H	TCGA-D1-A17D	UCEC	TCGA	SEVKVPEF	DEG_COP1_1	0.3056
p.G877C	DO228974	LICA	ICGC	SEVKVPEF	DEG_COP1_1	0.1111
p.R864K	DO29578	OV	ICGC	SEVKVPEF	DEG_COP1_1	0.7237
p.R875C	DO42201	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	0.1667
p.S865P	DO52402	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	0.6752
p.F852L	DO41211	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	0.0556
p.Y858C	DO41331	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	0.2222
p.P877S	SIDM00007	Other Solid Cancers	GDSC	SEVKVPEF	DEG_COP1_1	0.1111
p.P877S	MCC13	skin	COSMIC	SEVKVPEF	DEG_COP1_1	0.1111
p.R856S	SIDM01045	Endometrial Carcinoma	GDSC	SEVKVPEF	DEG_COP1_1	0.1667
p.R856S	EN	endometrium	COSMIC	SEVKVPEF	DEG_COP1_1	0.1667
p.A878V	ACH-000973	Bladder Cancer	CCLE	SEVKVPEF	DEG_COP1_1	0.0833
p.S874C	ACH-002123	Lung Cancer	CCLE	SEVKVPEF	DEG_COP1_1	0.1944
p.S874C	H2369	pleura	COSMIC	SEVKVPEF	DEG_COP1_1	0.1944
p.R875H	TE-4	oesophagus	COSMIC	SEVKVPEF	DEG_COP1_1	0.1667
p.S857C	H2369	pleura	COSMIC	SEVKVPEF	DEG_COP1_1	0.1944
p.R860S	EN	endometrium	COSMIC	SEVKVPEF	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_COP1_1	862:869	SEVKVPEF	COP1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons