DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_SCF_FBW7_2

Location: 621:628

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 100.7375

COIL: 0.7839

CONS_SCORE: 0.3577

DSS_SCORE: 0.5933

HELIX: 0.1834

FCONS_SCORE: 1.0839

RIG_SCORE: 0.7147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T622S	TCGA-21-1078	LUSC	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	0.7116
p.G634V	TCGA-95-7039	LUAD	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	0.1667
p.P619L	TCGA-AA-3864	COAD	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	0.2778
p.P613S	TCGA-DY-A1DG	READ	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	0.1111
p.Q628H	DO229031	LICA	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.7582
p.T618I	DO46657	PAAD	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.25
p.P621T	DO37738	SKCM	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.7031
p.H633Y	DO219501	SKCM	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.1944
p.T620S	DO41608	UCEC	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.3056
p.A624T	DO41791	UCEC	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	0.7139
p.P631L	CP66-MEL	skin	COSMIC	LRKTPVSE	DEG_SCF_FBW7_2	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SCF_FBW7_2	621:628	LRKTPVSE	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons