DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_Kelch_Keap1_1

Location: 536:541

E3 ligase: KEAP1

DEGRON score: 0.9942

ASA_SCORE: 93.1833

COIL: 0.922

CONS_SCORE: 0.3583

DSS_SCORE: 0.4736

HELIX: 0.052

FCONS_SCORE: 0.9946

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R531Q	TCGA-A8-A06Q	BRCA	TCGA	NCDTGE	DEG_Kelch_Keap1_1	0.1944
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	NCDTGE	DEG_Kelch_Keap1_1	0.1944
p.R531Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	0.1944
p.N532H	TCGA-AY-A54L	COAD	TCGA	NCDTGE	DEG_Kelch_Keap1_1	0.2222
p.D538G	TCGA-KK-A59V	PRAD	TCGA	NCDTGE	DEG_Kelch_Keap1_1	0.7198
p.A545T	DO219749	CESC	ICGC	NCDTGE	DEG_Kelch_Keap1_1	0.2222
p.A546S	DO229028	LICA	ICGC	NCDTGE	DEG_Kelch_Keap1_1	0.1944
p.G534R	DO27468	LUSC	ICGC	NCDTGE	DEG_Kelch_Keap1_1	0.7222
p.L535M	DO36556	READ	ICGC	NCDTGE	DEG_Kelch_Keap1_1	0.3056
p.S534G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	NCDTGE	DEG_Kelch_Keap1_1	0.7222
p.S534G	ACH-002102	Lung Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	0.7222
p.S534G	EMC-BAC-2	lung	COSMIC	NCDTGE	DEG_Kelch_Keap1_1	0.7222
p.V545A	SIDM00221	Melanoma	GDSC	NCDTGE	DEG_Kelch_Keap1_1	0.2222
p.V545A	ACH-002388	Skin Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	0.2222
p.N536K	ACH-001061	Colon/Colorectal Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_Kelch_Keap1_1	536:541	NCDTGE	KEAP1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons