DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_APCC_KENBOX_2

Location: 547:551

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7656

ASA_SCORE: 95.08

COIL: 0.6614

CONS_SCORE: 0.3747

DSS_SCORE: 0.5108

HELIX: 0.2652

FCONS_SCORE: 1.088

RIG_SCORE: 0.8056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K554N	DO1285	BRCA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.25
p.R560Q	DO1263	BRCA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.0833
p.R560Q	DO43907	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	0.0833
p.A545T	DO219749	CESC	ICGC	FKENI	DEG_APCC_KENBOX_2	0.2778
p.N561H	DO44091	COAD	ICGC	FKENI	DEG_APCC_KENBOX_2	0.0556
p.S559N	DO8730	COAD	ICGC	FKENI	DEG_APCC_KENBOX_2	0.1111
p.K553I	DO219656	KIRP	ICGC	FKENI	DEG_APCC_KENBOX_2	0.2778
p.A546S	DO229028	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.3056
p.K550E	DO51749	STAD	ICGC	FKENI	DEG_APCC_KENBOX_2	0.7022
p.L558F	SIDM01129	Small Cell Lung Carcinoma	GDSC	FKENI	DEG_APCC_KENBOX_2	0.1389
p.L558F	NCI-H524	lung	COSMIC	FKENI	DEG_APCC_KENBOX_2	0.1389
p.V545A	SIDM00221	Melanoma	GDSC	FKENI	DEG_APCC_KENBOX_2	0.2778
p.V545A	ACH-002388	Skin Cancer	CCLE	FKENI	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_APCC_KENBOX_2	547:551	FKENI	APC,CDC20,FZR1	0.7656	More...
Q9BX26	Synaptonemal complex protein 2	DEG_APCC_KENBOX_2	1043:1047	FKENI	APC,CDC20,FZR1	0.9572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons