DegronMD - Q8N4U5(TCP11L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S279A	TCGA-55-7911	LUAD	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.2222
p.S279A	DO24821	LUAD	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.2222
p.V60L	TCGA-69-7979	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1944
p.V60L	DO23874	LUAD	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1944
p.S45C	TCGA-A8-A08L	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.S45C	DO3110	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.E273K	TCGA-AG-4001	READ	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0556
p.E273K	TCGA-BG-A222	UCEC	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0556
p.E273K	DO220910	MELA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0556
p.E273K	DO36654	READ	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0556
p.E273K	DO42977	UCEC	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0556
p.L295M	TCGA-AP-A1DK	UCEC	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1389
p.L295M	DO42033	UCEC	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1389
p.S50Y	TCGA-AX-A060	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.S50Y	DO42576	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.L295P	TCGA-BR-8591	STAD	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1389
p.L295P	DO47973	STAD	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1389
p.E274D	TCGA-CS-6668	LGG	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0833
p.E274D	DO22548	LGG	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.0833
p.A287D	TCGA-D8-A1JD	BRCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.6682
p.A287D	DO1697	BRCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.6682
p.E288K	TCGA-EE-A2MR	SKCM	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.7022
p.E288K	DO37819	SKCM	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.7022
p.S291C	TCGA-XF-A9ST	BLCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.25
p.S291C	DO223599	BLCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.25
p.L278V	TCGA-XF-A9T0	BLCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1944
p.L278V	DO51920	BLCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1944
p.L278V	ACH-001838	Bile Duct Cancer	CCLE	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.1944
p.A41T	DO229010	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO229016	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO229003	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO229005	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO223114	ESCA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO229505	LAML	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO229047	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO230937	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO230993	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.A41T	DO230990	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.S45F	DO233252	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.P285H	DO233767	GACA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.7694
p.V59L	DO233722	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.A287S	DO229026	LICA	ICGC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation altering degron motif	0.6477
p.S46N	SIDM01878	Non-Cancerous	GDSC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation blocking phosphorylation signal	0.6389
p.S46N	SIDM00053	Pancreatic Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	51:55	Mutation blocking phosphorylation signal	0.6389
p.S46N	ACH-002360	Non-Cancerous	CCLE	PASTS	DEG_SPOP_SBC_1	51:55	Mutation blocking phosphorylation signal	0.6389
p.A282S	SIDM00263	Ewing's Sarcoma	GDSC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.3056
p.A282S	ACH-002106	Bone Cancer	CCLE	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.3056
p.A282S	ES5	bone	COSMIC	LTPGAE	DEG_SCF_FBW7_2	283:288	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCP11L2

UniProt ID: Q8N4U5

Entrez ID: 255394

Protein name: T-complex protein 11-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCP11L2 in