DegronMD

Uniprot ID: Q8N4U5

Source protein: T-complex protein 11-like protein 2

Source gene: TCP11L2

Class: DEG_SCF_FBW7_2

Location: 283:288

E3 ligase: FBXW7

DEGRON score: 0.949

ASA_SCORE: 75.0333

COIL: 0.8038

CONS_SCORE: 0.3748

DSS_SCORE: 0.515

HELIX: 0.1557

FCONS_SCORE: 1.3565

RIG_SCORE: 0.6409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S279A	TCGA-55-7911	LUAD	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.2222
p.S279A	DO24821	LUAD	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.2222
p.E273K	TCGA-AG-4001	READ	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.0556
p.E273K	TCGA-BG-A222	UCEC	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.0556
p.E273K	DO220910	MELA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.0556
p.E273K	DO36654	READ	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.0556
p.E273K	DO42977	UCEC	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.0556
p.L295M	TCGA-AP-A1DK	UCEC	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.1389
p.L295M	DO42033	UCEC	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.1389
p.L295P	TCGA-BR-8591	STAD	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.1389
p.L295P	DO47973	STAD	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.1389
p.E274D	TCGA-CS-6668	LGG	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.0833
p.E274D	DO22548	LGG	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.0833
p.A287D	TCGA-D8-A1JD	BRCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.6682
p.A287D	DO1697	BRCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.6682
p.E288K	TCGA-EE-A2MR	SKCM	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.7022
p.E288K	DO37819	SKCM	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.7022
p.S291C	TCGA-XF-A9ST	BLCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.25
p.S291C	DO223599	BLCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.25
p.L278V	TCGA-XF-A9T0	BLCA	TCGA	LTPGAE	DEG_SCF_FBW7_2	0.1944
p.L278V	DO51920	BLCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.1944
p.L278V	ACH-001838	Bile Duct Cancer	CCLE	LTPGAE	DEG_SCF_FBW7_2	0.1944
p.P285H	DO233767	GACA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.7694
p.A287S	DO229026	LICA	ICGC	LTPGAE	DEG_SCF_FBW7_2	0.6477
p.A282S	SIDM00263	Ewing's Sarcoma	GDSC	LTPGAE	DEG_SCF_FBW7_2	0.3056
p.A282S	ACH-002106	Bone Cancer	CCLE	LTPGAE	DEG_SCF_FBW7_2	0.3056
p.A282S	ES5	bone	COSMIC	LTPGAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_SCF_FBW7_2	956:961	LTPGAE	FBXW7	0.9883	More...
Q8N4U5	T-complex protein 11-like protein 2	DEG_SCF_FBW7_2	283:288	LTPGAE	FBXW7	0.949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons