DegronMD

Uniprot ID: O94973

Source protein: AP-2 complex subunit alpha-2

Source gene: AP2A2

Class: DEG_SPOP_SBC_1

Location: 646:650

E3 ligase: SPOP

DEGRON score: 0.827

ASA_SCORE: 74

COIL: 0.8526

CONS_SCORE: 0.2739

DSS_SCORE: 0.7275

HELIX: 0.1168

FCONS_SCORE: 0.9403

RIG_SCORE: 0.5962

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A648T	DO233146	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.7139
p.P645R	DO32410	OV	ICGC	PASTS	DEG_SPOP_SBC_1	0.3056
p.P644R	TCGA-61-1919	OV	TCGA	PASTS	DEG_SPOP_SBC_1	0.2778
p.G641R	SIDM00499	Prostate Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.1944
p.G641R	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.1944
p.G641R	SNU-1040	large_intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	0.1944
p.G641R	22RV1	prostate	COSMIC	PASTS	DEG_SPOP_SBC_1	0.1944
p.G640R	ACH-000956	Prostate Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.1667
p.G640R	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.1667
p.G640R	SNU-1040	large_intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	0.1667
p.G640R	22RV1	prostate	COSMIC	PASTS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 11 of 11 entries

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Drug responses associated with AP2A2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PASTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	DEG_SPOP_SBC_1	927:931	PASTS	SPOP	0.985	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2005:2009	PASTS	SPOP	0.9657	More...
O94973	AP-2 complex subunit alpha-2	DEG_SPOP_SBC_1	646:650	PASTS	SPOP	0.827	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	365:369	PASTS	SPOP	0.954	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	126:130	PASTS	SPOP	0.8075	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2725:2729	PASTS	SPOP	0.999	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1016:1020	PASTS	SPOP	0.5066	More...
O95208	Epsin-2	DEG_SPOP_SBC_1	372:376	PASTS	SPOP	0.9841	More...
A8MTJ6	Forkhead box protein I3	DEG_SPOP_SBC_1	387:391	PASTS	SPOP	0.9013	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	356:360	PASTS	SPOP	0.6906	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	463:467	PASTS	SPOP	0.9585	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	419:423	PASTS	SPOP	0.9906	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	188:192	PASTS	SPOP	0.5868	More...
Q9Y4C1	Lysine-specific demethylase 3A	DEG_SPOP_SBC_1	815:819	PASTS	SPOP	0.9164	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	993:997	PASTS	SPOP	0.8792	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	549:553	PASTS	SPOP	0.7898	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	556:560	PASTS	SPOP	0.7232	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	650:654	PASTS	SPOP	0.9948	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	11:15	PASTS	SPOP	0.9977	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	1181:1185	PASTS	SPOP	0.9984	More...
Q6NSJ2	Pleckstrin homology-like domain family B member 3	DEG_SPOP_SBC_1	85:89	PASTS	SPOP	0.9511	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	928:932	PASTS	SPOP	0.9499	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1763:1767	PASTS	SPOP	0.9781	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1778:1782	PASTS	SPOP	0.9401	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1820:1824	PASTS	SPOP	0.8745	More...

Showing 1 to 25 of 39 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTS

Degron related mutations and impact score

Drug responses associated with AP2A2 mutations

All proteins holding degron of PASTS