DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 549:553

E3 ligase: SPOP

DEGRON score: 0.7898

ASA_SCORE: 85.82

COIL: 0.8766

CONS_SCORE: 0

DSS_SCORE: 0.5969

HELIX: 0.019

FCONS_SCORE: 0

RIG_SCORE: 0.6436

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P541A	TCGA-66-2785	LUSC	TCGA	PASTS	DEG_SPOP_SBC_1	0.1111
p.P541A	DO26520	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.1111
p.P548S	TCGA-AX-A0J1	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	0.3056
p.P548S	DO41199	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	0.3056
p.K544E	TCGA-CD-5801	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.3056
p.K544E	DO38563	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.3056
p.M543I	TCGA-D3-A5GN	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	0.1667
p.M543I	DO47317	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	0.1667
p.E546K	TCGA-EE-A29V	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	0.25
p.E546K	TCGA-GN-A267	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	0.25
p.E546K	DO218874	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.25
p.E546K	DO38006	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	0.25
p.E546K	DO38147	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	0.25
p.S561F	TCGA-EE-A3J7	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	0.1111
p.S561F	DO220886	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	0.1111
p.S561F	DO48770	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	0.1111
p.P548T	TCGA-EQ-A4SO	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.3056
p.P548T	DO47893	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.3056
p.T545A	DO228483	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO229010	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO229013	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO230529	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO52365	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO231078	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO231007	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.T545A	DO231022	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.P563S	DO233168	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.0556
p.P563S	ACH-000987	Skin Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.0556
p.P563S	Mewo	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	0.0556
p.P541S	DO229462	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.1111
p.P563L	SIDM00545	Melanoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.0556
p.P563L	ACH-000987	Skin Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.0556
p.P563L	Mewo	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	0.0556
p.V562A	SIDM00683	Prostate Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.0833
p.V562A	LNCaP-Clone-FGC	prostate	COSMIC	PASTS	DEG_SPOP_SBC_1	0.0833
p.A550S	SIDM01611	Endometrial Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.6477
p.A550S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.6477
p.P549A	SIDM01321	Pancreatic Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.6392
p.P549A	ACH-000307	Pancreatic Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	308:312	PASTS	SPOP	0.9913	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	993:997	PASTS	SPOP	0.8792	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2725:2729	PASTS	SPOP	0.999	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	11:15	PASTS	SPOP	0.9977	More...
O94973	AP-2 complex subunit alpha-2	DEG_SPOP_SBC_1	646:650	PASTS	SPOP	0.827	More...
O95208	Epsin-2	DEG_SPOP_SBC_1	372:376	PASTS	SPOP	0.9841	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	2657:2661	PASTS	SPOP	0.9979	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	365:369	PASTS	SPOP	0.954	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	345:349	PASTS	SPOP	0.9474	More...
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	DEG_SPOP_SBC_1	927:931	PASTS	SPOP	0.985	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	556:560	PASTS	SPOP	0.7232	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	1181:1185	PASTS	SPOP	0.9984	More...
Q16621	Transcription factor NF-E2 45 kDa subunit	DEG_SPOP_SBC_1	86:90	PASTS	SPOP	0.9466	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	463:467	PASTS	SPOP	0.9585	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	1236:1240	PASTS	SPOP	0.9958	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	419:423	PASTS	SPOP	0.9906	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1016:1020	PASTS	SPOP	0.5066	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2005:2009	PASTS	SPOP	0.9657	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	549:553	PASTS	SPOP	0.7898	More...
Q99469	SH3 and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	28:32	PASTS	SPOP	0.9799	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	650:654	PASTS	SPOP	0.9948	More...
Q9NWS9	Zinc finger protein 446	DEG_SPOP_SBC_1	198:202	PASTS	SPOP	0.9975	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	126:130	PASTS	SPOP	0.8075	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	356:360	PASTS	SPOP	0.6906	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	928:932	PASTS	SPOP	0.9499	More...
Q9Y4C1	Lysine-specific demethylase 3A	DEG_SPOP_SBC_1	815:819	PASTS	SPOP	0.9164	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1763:1767	PASTS	SPOP	0.9781	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1778:1782	PASTS	SPOP	0.9401	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1820:1824	PASTS	SPOP	0.8745	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	188:192	PASTS	SPOP	0.5868	More...
Q6IEE8	Schlafen family member 12-like	DEG_SPOP_SBC_1	372:376	PASTS	SPOP	0.7893	More...
Q6NSJ2	Pleckstrin homology-like domain family B member 3	DEG_SPOP_SBC_1	85:89	PASTS	SPOP	0.9511	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SPOP_SBC_1	753:757	PASTS	SPOP	0.9882	More...
Q8N4U5	T-complex protein 11-like protein 2	DEG_SPOP_SBC_1	51:55	PASTS	SPOP	0.9613	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	467:471	PASTS	SPOP	0.9948	More...
A8MTJ6	Forkhead box protein I3	DEG_SPOP_SBC_1	387:391	PASTS	SPOP	0.9013	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	482:486	PASTS	SPOP	0.9926	More...
Q8NCL8	Transmembrane protein 116	DEG_SPOP_SBC_1	238:242	PASTS	SPOP	0.963	More...
Q8WTZ4	Putative inactive carbonic anhydrase 5B-like protein	DEG_SPOP_SBC_1	5:9	PASTS	SPOP	0.7966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PASTS