DegronMD - O94973(AP2A2)

FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P644R	TCGA-61-1919	OV	TCGA	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.1111
p.P644R	TCGA-61-1919	OV	TCGA	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2778
p.S693Y	TCGA-AP-A1DV	UCEC	TCGA	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.25
p.S693Y	DO43186	UCEC	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.25
p.A696V	TCGA-B5-A5OC	UCEC	TCGA	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1667
p.A696V	DO229221	THCA	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1667
p.A696V	DO52405	UCEC	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1667
p.R607W	TCGA-BB-4228	HNSC	TCGA	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.3056
p.P657L	TCGA-D1-A17Q	UCEC	TCGA	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6471
p.P657L	DO41903	UCEC	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6471
p.P657L	ACH-001388	Breast Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6471
p.V652A	TCGA-D7-A6EY	STAD	TCGA	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6936
p.V652A	DO50118	STAD	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6936
p.V597M	TCGA-FI-A2D5	UCEC	TCGA	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2222
p.V597M	DO41331	UCEC	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2222
p.I611M	TCGA-IR-A3LH	CESC	TCGA	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.1944
p.I611M	DO44381	CESC	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.1944
p.P602L	TCGA-WS-AB45	COAD	TCGA	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation altering degron motif	0.6471
p.P602L	DO51734	COAD	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation altering degron motif	0.6471
p.T654M	DO49242	ALL	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.7423
p.L698F	DO828	BLCA	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1111
p.T654R	DO225169	BRCA	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.7876
p.P603S	DO229010	COCA	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation altering degron motif	0.6752
p.A648T	DO233146	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.7139
p.G680S	DO233737	GACA	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1944
p.G680S	DO51053	PRAD	ICGC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1944
p.R608W	DO15262	HNSC	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2778
p.R608W	DO35242	PACA	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2778
p.L616F	DO23502	LINC	ICGC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation substituting flanking lysine	0.1667
p.P645R	DO32410	OV	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.1389
p.P645R	DO32410	OV	ICGC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.P657S	DO229268	THCA	ICGC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.5641
p.P698S	SIDM01945	Colorectal Carcinoma	GDSC	VDVFSD	LIG_APCC_ABBA_1	685:690	Mutation rewiring degron network	0.1111
p.G641R	SIDM00499	Prostate Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.G641R	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.G641R	SNU-1040	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.G641R	22RV1	prostate	COSMIC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.V653M	SIDM00321	Ovarian Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.7208
p.V653M	SIDM01095	Rhabdomyosarcoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.7208
p.A668V	SIDM00194	Colorectal Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.0556
p.A668V	SNU-61	large intestine	COSMIC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.0556
p.E609D	SIDM00836	Colorectal Carcinoma	GDSC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.25
p.E609D	SW403	large intestine	COSMIC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.25
p.S658L	ACH-000170	Non-Cancerous	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.7667
p.V652M	ACH-000430	Ovarian Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6097
p.V652M	ACH-000833	Sarcoma	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6097
p.V652M	ACH-001736	Leukemia	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation altering degron motif	0.6097
p.A667V	ACH-000532	Colon/Colorectal Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.0833
p.A667V	SNU-61	large intestine	COSMIC	VSTPSPS	DEG_SCF_FBW7_1	652:658	Mutation rewiring degron network	0.0833
p.E608D	ACH-000820	Colon/Colorectal Cancer	CCLE	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2778
p.E608D	SW403	large intestine	COSMIC	MPPFPE	LIG_APCC_ABBA_1	601:606	Mutation rewiring degron network	0.2778
p.G640R	ACH-000956	Prostate Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.G640R	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.G640R	SNU-1040	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.G640R	22RV1	prostate	COSMIC	PASTS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667

Kaplan plot for AP2A2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AP2A2

UniProt ID: O94973

Entrez ID: 161

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AP2A2 in