DegronMD

Uniprot ID: O94973

Source protein: AP-2 complex subunit alpha-2

Source gene: AP2A2

Class: LIG_APCC_ABBA_1

Location: 685:690

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7373

ASA_SCORE: 71.9833

COIL: 0.6478

CONS_SCORE: 0.3455

DSS_SCORE: 0.2619

HELIX: 0.2188

FCONS_SCORE: 1.2897

RIG_SCORE: 0.7917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S693Y	TCGA-AP-A1DV	UCEC	TCGA	VDVFSD	LIG_APCC_ABBA_1	0.25
p.S693Y	DO43186	UCEC	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.25
p.A696V	TCGA-B5-A5OC	UCEC	TCGA	VDVFSD	LIG_APCC_ABBA_1	0.1667
p.A696V	DO229221	THCA	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.1667
p.A696V	DO52405	UCEC	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.1667
p.L698F	DO828	BLCA	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.1111
p.G680S	DO233737	GACA	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.1944
p.G680S	DO51053	PRAD	ICGC	VDVFSD	LIG_APCC_ABBA_1	0.1944
p.P698S	SIDM01945	Colorectal Carcinoma	GDSC	VDVFSD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94973	AP-2 complex subunit alpha-2	LIG_APCC_ABBA_1	685:690	VDVFSD	APC,CDC20,FZR1	0.7373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons