DegronMD

Uniprot ID: O94973

Source protein: AP-2 complex subunit alpha-2

Source gene: AP2A2

Class: LIG_APCC_ABBA_1

Location: 601:606

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 80.1667

COIL: 0.7918

CONS_SCORE: 0.6323

DSS_SCORE: 0.3723

HELIX: 0.1825

FCONS_SCORE: 1.2657

RIG_SCORE: 0.7465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R607W	TCGA-BB-4228	HNSC	TCGA	MPPFPE	LIG_APCC_ABBA_1	0.3056
p.V597M	TCGA-FI-A2D5	UCEC	TCGA	MPPFPE	LIG_APCC_ABBA_1	0.2222
p.V597M	DO41331	UCEC	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.2222
p.I611M	TCGA-IR-A3LH	CESC	TCGA	MPPFPE	LIG_APCC_ABBA_1	0.1944
p.I611M	DO44381	CESC	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.1944
p.P602L	TCGA-WS-AB45	COAD	TCGA	MPPFPE	LIG_APCC_ABBA_1	0.6471
p.P602L	DO51734	COAD	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.6471
p.P603S	DO229010	COCA	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.6752
p.R608W	DO15262	HNSC	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.2778
p.R608W	DO35242	PACA	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.2778
p.L616F	DO23502	LINC	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.1667
p.E609D	SIDM00836	Colorectal Carcinoma	GDSC	MPPFPE	LIG_APCC_ABBA_1	0.25
p.E609D	SW403	large_intestine	COSMIC	MPPFPE	LIG_APCC_ABBA_1	0.25
p.E608D	ACH-000820	Colon/Colorectal Cancer	CCLE	MPPFPE	LIG_APCC_ABBA_1	0.2778
p.E608D	SW403	large_intestine	COSMIC	MPPFPE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons