DegronMD

Uniprot ID: O95782

Source protein: AP-2 complex subunit alpha-1

Source gene: AP2A1

Class: LIG_APCC_ABBA_1

Location: 602:607

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9978

ASA_SCORE: 79.3167

COIL: 0.825

CONS_SCORE: 0.5689

DSS_SCORE: 0.402

HELIX: 0.151

FCONS_SCORE: 1.1995

RIG_SCORE: 0.7526

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I612V	DO51474	PACA	ICGC	MPPFPE	LIG_APCC_ABBA_1	0.1944
p.P604S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MPPFPE	LIG_APCC_ABBA_1	0.6752
p.P604S	ACH-001127	Leukemia	CCLE	MPPFPE	LIG_APCC_ABBA_1	0.6752
p.P604S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MPPFPE	LIG_APCC_ABBA_1	0.6752
p.S610P	ACH-001377	Pancreatic Cancer	CCLE	MPPFPE	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons