DegronMD

Uniprot ID: O94973

Source protein: AP-2 complex subunit alpha-2

Source gene: AP2A2

Class: DEG_SCF_FBW7_1

Location: 652:658

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 74.9714

COIL: 0.9059

CONS_SCORE: 0.2944

DSS_SCORE: 0.6194

HELIX: 0.0724

FCONS_SCORE: 1.0666

RIG_SCORE: 0.5945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P644R	TCGA-61-1919	OV	TCGA	VSTPSPS	DEG_SCF_FBW7_1	0.1111
p.P657L	TCGA-D1-A17Q	UCEC	TCGA	VSTPSPS	DEG_SCF_FBW7_1	0.6471
p.P657L	DO41903	UCEC	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.6471
p.P657L	ACH-001388	Breast Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.6471
p.V652A	TCGA-D7-A6EY	STAD	TCGA	VSTPSPS	DEG_SCF_FBW7_1	0.6936
p.V652A	DO50118	STAD	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.6936
p.T654M	DO49242	ALL	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.7423
p.T654R	DO225169	BRCA	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.7876
p.P645R	DO32410	OV	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.1389
p.P657S	DO229268	THCA	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.5641
p.V653M	SIDM00321	Ovarian Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	0.7208
p.V653M	SIDM01095	Rhabdomyosarcoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	0.7208
p.A668V	SIDM00194	Colorectal Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	0.0556
p.A668V	SNU-61	large_intestine	COSMIC	VSTPSPS	DEG_SCF_FBW7_1	0.0556
p.S658L	ACH-000170	Non-Cancerous	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.7667
p.V652M	ACH-000430	Ovarian Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.6097
p.V652M	ACH-000833	Sarcoma	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.6097
p.V652M	ACH-001736	Leukemia	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.6097
p.A667V	ACH-000532	Colon/Colorectal Cancer	CCLE	VSTPSPS	DEG_SCF_FBW7_1	0.0833
p.A667V	SNU-61	large_intestine	COSMIC	VSTPSPS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons