DegronMD

Uniprot ID: O95782

Source protein: AP-2 complex subunit alpha-1

Source gene: AP2A1

Class: DEG_SCF_FBW7_1

Location: 651:657

E3 ligase: FBXW7

DEGRON score: 0.9723

ASA_SCORE: 72.0286

COIL: 0.882

CONS_SCORE: 0.231

DSS_SCORE: 0.6687

HELIX: 0.0831

FCONS_SCORE: 0.8336

RIG_SCORE: 0.6027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G642W	TCGA-A6-2686	COAD	TCGA	VSTPSPS	DEG_SCF_FBW7_1	0.0833
p.G642W	DO7828	COAD	ICGC	VSTPSPS	DEG_SCF_FBW7_1	0.0833
p.A666S	SIDM01314	Colorectal Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	0.0833
p.T653M	SIDM01308	Esophageal Carcinoma	GDSC	VSTPSPS	DEG_SCF_FBW7_1	0.8534

DegronMD: protein-targeted degradation, mutation and drug response to degrons