DegronMD - Q9Y4C1(KDM3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T842P	TCGA-AJ-A3EL	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation blocking phosphorylation signal	0.6389
p.T842P	DO41542	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation blocking phosphorylation signal	0.6389
p.S829N	TCGA-AO-A03V	BRCA	TCGA	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.2222
p.S829N	TCGA-AO-A03V	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0556
p.S829N	DO2443	BRCA	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.2222
p.S829N	DO2443	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0556
p.K847N	TCGA-AP-A1DV	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation blocking ubiquitination signal	0.5
p.K847N	DO43186	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation blocking ubiquitination signal	0.5
p.I845L	TCGA-AX-A0J0	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1111
p.I845L	DO41133	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1111
p.T818A	TCGA-XK-AAIW	PRAD	TCGA	PASTS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7139
p.T818A	DO51407	PRAD	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7139
p.D826N	DO229003	COCA	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	DO229003	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	DO52346	LUSC	ICGC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	DO52346	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	SIDM00277	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	SIDM00277	Acute Myeloid Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	SIDM00260	Gastric Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	SIDM00260	Gastric Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	SIDM00363	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	SIDM00363	Acute Myeloid Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	SIDM00248	Gastric Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	SIDM00248	Gastric Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.D826N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1389
p.D826N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.P820T	DO223061	ESCA	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.S809N	DO231937	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1667
p.Q840R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.25
p.Q840R	ACH-000920	Leukemia	CCLE	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.25
p.Q840R	CML-T1	haematopoietic and lymphoid tissue	COSMIC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.25
p.T828S	SIDM00018	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1944
p.T828S	SIDM00018	Acute Myeloid Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0833
p.T828S	KO52	haematopoietic and lymphoid tissue	COSMIC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.1944
p.T828S	KO52	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0833
p.N831H	SIDM00118	Colorectal Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.2778
p.N831H	ACH-001081	Colon/Colorectal Cancer	CCLE	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.2778
p.N831H	HCC2998	large intestine	COSMIC	NKENK	DEG_APCC_KENBOX_2	833:837	Mutation rewiring degron network	0.2778

Kaplan plot for KDM3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM3A

UniProt ID: Q9Y4C1

Entrez ID: 55818

Protein name: Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM3A in