DegronMD

Uniprot ID: Q9Y4C1

Source protein: Lysine-specific demethylase 3A

Source gene: KDM3A

Class: DEG_APCC_KENBOX_2

Location: 833:837

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7917

ASA_SCORE: 97.5

COIL: 0.7

CONS_SCORE: 0.4718

DSS_SCORE: 0.5791

HELIX: 0.2644

FCONS_SCORE: 1.042

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T842P	TCGA-AJ-A3EL	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	0.6389
p.T842P	DO41542	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	0.6389
p.S829N	TCGA-AO-A03V	BRCA	TCGA	NKENK	DEG_APCC_KENBOX_2	0.2222
p.S829N	DO2443	BRCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.2222
p.K847N	TCGA-AP-A1DV	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	0.5
p.K847N	DO43186	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	0.5
p.I845L	TCGA-AX-A0J0	UCEC	TCGA	NKENK	DEG_APCC_KENBOX_2	0.1111
p.I845L	DO41133	UCEC	ICGC	NKENK	DEG_APCC_KENBOX_2	0.1111
p.D826N	DO229003	COCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	DO52346	LUSC	ICGC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	SIDM00277	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	SIDM00260	Gastric Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	SIDM00363	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	SIDM00248	Gastric Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.D826N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1389
p.Q840R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	0.25
p.Q840R	ACH-000920	Leukemia	CCLE	NKENK	DEG_APCC_KENBOX_2	0.25
p.Q840R	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENK	DEG_APCC_KENBOX_2	0.25
p.T828S	SIDM00018	Acute Myeloid Leukemia	GDSC	NKENK	DEG_APCC_KENBOX_2	0.1944
p.T828S	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	NKENK	DEG_APCC_KENBOX_2	0.1944
p.N831H	SIDM00118	Colorectal Carcinoma	GDSC	NKENK	DEG_APCC_KENBOX_2	0.2778
p.N831H	ACH-001081	Colon/Colorectal Cancer	CCLE	NKENK	DEG_APCC_KENBOX_2	0.2778
p.N831H	HCC2998	large_intestine	COSMIC	NKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47974	mRNA decay activator protein ZFP36L2	DEG_APCC_KENBOX_2	114:118	NKENK	APC,CDC20,FZR1	0.9879	More...
Q86T82	Ubiquitin carboxyl-terminal hydrolase 37	DEG_APCC_KENBOX_2	781:785	NKENK	APC,CDC20,FZR1	0.9057	More...
Q9Y4C1	Lysine-specific demethylase 3A	DEG_APCC_KENBOX_2	833:837	NKENK	APC,CDC20,FZR1	0.7917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENK

Degron related mutations and impact score

Drug responses associated with KDM3A mutations

All proteins holding degron of NKENK