DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NKENK
Uniprot ID:
Q86T82
Source protein:
Ubiquitin carboxyl-terminal hydrolase 37
Source gene:
USP37
Class:
DEG_APCC_KENBOX_2
Location:
781:785
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9057
ASA_SCORE:
108.28
COIL:
0.8166
CONS_SCORE:
0.3541
DSS_SCORE:
0.6925
HELIX:
0.1122
FCONS_SCORE:
1.0395
RIG_SCORE:
0.6471
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D777Y
TCGA-CL-5918
READ
TCGA
NKENK
DEG_APCC_KENBOX_2
0.2222
p.D777Y
DO36867
READ
ICGC
NKENK
DEG_APCC_KENBOX_2
0.2222
p.F771L
TCGA-ND-A4WC
UCS
TCGA
NKENK
DEG_APCC_KENBOX_2
0.0556
p.P787L
DO229557
PRAD
ICGC
NKENK
DEG_APCC_KENBOX_2
0.2778
p.K782N
DO46980
RECA
ICGC
NKENK
DEG_APCC_KENBOX_2
0.6918
p.D771E
ACH-000425
Skin Cancer
CCLE
NKENK
DEG_APCC_KENBOX_2
0.0556
p.D771E
ACH-002004
Skin Cancer
CCLE
NKENK
DEG_APCC_KENBOX_2
0.0556
p.D771E
UACC-62
skin
COSMIC
NKENK
DEG_APCC_KENBOX_2
0.0556
p.L782R
ACH-000898
Gastric Cancer
CCLE
NKENK
DEG_APCC_KENBOX_2
0.8428
Drug responses associated with USP37 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKENK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P47974
mRNA decay activator protein ZFP36L2
DEG_APCC_KENBOX_2
114:118
NKENK
APC,CDC20,FZR1
0.9879
More...
Q86T82
Ubiquitin carboxyl-terminal hydrolase 37
DEG_APCC_KENBOX_2
781:785
NKENK
APC,CDC20,FZR1
0.9057
More...
Q9Y4C1
Lysine-specific demethylase 3A
DEG_APCC_KENBOX_2
833:837
NKENK
APC,CDC20,FZR1
0.7917
More...