DegronMD

Uniprot ID: P47974

Source protein: mRNA decay activator protein ZFP36L2

Source gene: ZFP36L2

Class: DEG_APCC_KENBOX_2

Location: 114:118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9879

ASA_SCORE: 107.4

COIL: 0.5692

CONS_SCORE: 0.3208

DSS_SCORE: 0.5708

HELIX: 0.415

FCONS_SCORE: 0.9861

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E126Q	TCGA-BH-A0W7	BRCA	TCGA	NKENK	DEG_APCC_KENBOX_2	0.1111
p.E126Q	DO1272	BRCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.1111
p.S123W	TCGA-E2-A10C	BRCA	TCGA	NKENK	DEG_APCC_KENBOX_2	0.6389
p.S123W	DO1334	BRCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.6389
p.R120L	TCGA-EE-A2MD	SKCM	TCGA	NKENK	DEG_APCC_KENBOX_2	0.2778
p.R120L	DO37851	SKCM	ICGC	NKENK	DEG_APCC_KENBOX_2	0.2778
p.S123L	TCGA-YC-A89H	BLCA	TCGA	NKENK	DEG_APCC_KENBOX_2	0.6389
p.S123L	DO51948	BLCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.6389
p.S105L	DO223030	ESCA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.0833
p.P104L	DO233944	GACA	ICGC	NKENK	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47974	mRNA decay activator protein ZFP36L2	DEG_APCC_KENBOX_2	114:118	NKENK	APC,CDC20,FZR1	0.9879	More...
Q86T82	Ubiquitin carboxyl-terminal hydrolase 37	DEG_APCC_KENBOX_2	781:785	NKENK	APC,CDC20,FZR1	0.9057	More...
Q9Y4C1	Lysine-specific demethylase 3A	DEG_APCC_KENBOX_2	833:837	NKENK	APC,CDC20,FZR1	0.7917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons