DegronMD - Q86T82(USP37)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K230M	TCGA-13-1477	OV	TCGA	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation substituting flanking lysine	0.2778
p.K230M	DO27978	OV	ICGC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation substituting flanking lysine	0.2778
p.D218H	TCGA-AO-A03T	BRCA	TCGA	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.2778
p.D218H	DO3215	BRCA	ICGC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.2778
p.S227L	TCGA-BS-A0UF	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.S227L	TCGA-DF-A2KU	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.S227L	DO223286	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.S227L	DO41488	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.S227L	SIDM00853	Other Sarcomas	GDSC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.S227L	GCT	soft tissue	COSMIC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.6944
p.D777Y	TCGA-CL-5918	READ	TCGA	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.2222
p.D777Y	DO36867	READ	ICGC	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.2222
p.F771L	TCGA-ND-A4WC	UCS	TCGA	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.0556
p.N228D	DO228617	LICA	ICGC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.2222
p.P787L	DO229557	PRAD	ICGC	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.2778
p.K782N	DO46980	RECA	ICGC	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation altering degron motif	0.6918
p.S226L	SIDM00767	Small Cell Lung Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.2778
p.S226L	NCI-H187	lung	COSMIC	PKEND	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.2778
p.D771E	ACH-000425	Skin Cancer	CCLE	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.0556
p.D771E	ACH-002004	Skin Cancer	CCLE	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.0556
p.D771E	UACC-62	skin	COSMIC	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation rewiring degron network	0.0556
p.L782R	ACH-000898	Gastric Cancer	CCLE	NKENK	DEG_APCC_KENBOX_2	781:785	Mutation altering degron motif	0.8428

Kaplan plot for USP37 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP37

UniProt ID: Q86T82

Entrez ID: 57695

Protein name: Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for USP37 in