DegronMD

Uniprot ID: Q86T82

Source protein: Ubiquitin carboxyl-terminal hydrolase 37

Source gene: USP37

Class: DEG_APCC_KENBOX_2

Location: 220:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9138

ASA_SCORE: 103.1

COIL: 0.9018

CONS_SCORE: 0.3589

DSS_SCORE: 0.6656

HELIX: 0.063

FCONS_SCORE: 0.8943

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K230M	TCGA-13-1477	OV	TCGA	PKEND	DEG_APCC_KENBOX_2	0.2778
p.K230M	DO27978	OV	ICGC	PKEND	DEG_APCC_KENBOX_2	0.2778
p.D218H	TCGA-AO-A03T	BRCA	TCGA	PKEND	DEG_APCC_KENBOX_2	0.2778
p.D218H	DO3215	BRCA	ICGC	PKEND	DEG_APCC_KENBOX_2	0.2778
p.S227L	TCGA-BS-A0UF	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	0.6944
p.S227L	TCGA-DF-A2KU	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	0.6944
p.S227L	DO223286	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	0.6944
p.S227L	DO41488	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	0.6944
p.S227L	SIDM00853	Other Sarcomas	GDSC	PKEND	DEG_APCC_KENBOX_2	0.6944
p.S227L	GCT	soft_tissue	COSMIC	PKEND	DEG_APCC_KENBOX_2	0.6944
p.N228D	DO228617	LICA	ICGC	PKEND	DEG_APCC_KENBOX_2	0.2222
p.S226L	SIDM00767	Small Cell Lung Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	0.2778
p.S226L	NCI-H187	lung	COSMIC	PKEND	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T82	Ubiquitin carboxyl-terminal hydrolase 37	DEG_APCC_KENBOX_2	220:224	PKEND	APC,CDC20,FZR1	0.9138	More...
Q9NWQ8	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	DEG_APCC_KENBOX_2	412:416	PKEND	APC,CDC20,FZR1	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons