DegronMD - Q9NWQ8(PAG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T404A	TCGA-AJ-A23O	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation blocking phosphorylation signal	0.5556
p.T404A	DO43290	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation blocking phosphorylation signal	0.5556
p.D422E	TCGA-B5-A5OE	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.1667
p.D422E	DO52408	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.1667
p.D416N	TCGA-EC-A24G	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.5821
p.D416N	DO40996	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.5821
p.S419R	TCGA-VD-A8KA	UVM	TCGA	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation blocking phosphorylation signal	0.6944
p.D416A	TCGA-VD-A8KA	UVM	TCGA	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.6682
p.K413E	SIDM00663	Melanoma	GDSC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.7022
p.K413E	ACH-000814	Skin Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.7022
p.K413E	Hs939-T	skin	COSMIC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation altering degron motif	0.7022
p.L423F	SIDM01055	Glioblastoma	GDSC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.1389
p.L423F	ACH-000098	Brain Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.1389
p.L423F	GAMG	central nervous system	COSMIC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.1389
p.V411I	SIDM00375	Head and Neck Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.3056
p.V411I	SIDM00163	Biliary Tract Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.3056
p.V411I	SIDM01640	Acute Myeloid Leukemia	GDSC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.3056
p.V411I	SKN-3	upper aerodigestive tract	COSMIC	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.3056
p.G409S	ACH-001843	Bile Duct Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	412:416	Mutation rewiring degron network	0.25

Kaplan plot for PAG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAG1

UniProt ID: Q9NWQ8

Entrez ID: 55824

Protein name: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAG1 in