DegronMD

Uniprot ID: Q9NWQ8

Source protein: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Source gene: PAG1

Class: DEG_APCC_KENBOX_2

Location: 412:416

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9912

ASA_SCORE: 83.8

COIL: 0.7766

CONS_SCORE: 0.6954

DSS_SCORE: 0.5831

HELIX: 0.179

FCONS_SCORE: 1.2315

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T404A	TCGA-AJ-A23O	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	0.5556
p.T404A	DO43290	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	0.5556
p.D422E	TCGA-B5-A5OE	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	0.1667
p.D422E	DO52408	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	0.1667
p.D416N	TCGA-EC-A24G	UCEC	TCGA	PKEND	DEG_APCC_KENBOX_2	0.5821
p.D416N	DO40996	UCEC	ICGC	PKEND	DEG_APCC_KENBOX_2	0.5821
p.S419R	TCGA-VD-A8KA	UVM	TCGA	PKEND	DEG_APCC_KENBOX_2	0.6944
p.D416A	TCGA-VD-A8KA	UVM	TCGA	PKEND	DEG_APCC_KENBOX_2	0.6682
p.K413E	SIDM00663	Melanoma	GDSC	PKEND	DEG_APCC_KENBOX_2	0.7022
p.K413E	ACH-000814	Skin Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	0.7022
p.K413E	Hs939-T	skin	COSMIC	PKEND	DEG_APCC_KENBOX_2	0.7022
p.L423F	SIDM01055	Glioblastoma	GDSC	PKEND	DEG_APCC_KENBOX_2	0.1389
p.L423F	ACH-000098	Brain Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	0.1389
p.L423F	GAMG	central_nervous_system	COSMIC	PKEND	DEG_APCC_KENBOX_2	0.1389
p.V411I	SIDM00375	Head and Neck Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	0.3056
p.V411I	SIDM00163	Biliary Tract Carcinoma	GDSC	PKEND	DEG_APCC_KENBOX_2	0.3056
p.V411I	SIDM01640	Acute Myeloid Leukemia	GDSC	PKEND	DEG_APCC_KENBOX_2	0.3056
p.V411I	SKN-3	upper_aerodigestive_tract	COSMIC	PKEND	DEG_APCC_KENBOX_2	0.3056
p.G409S	ACH-001843	Bile Duct Cancer	CCLE	PKEND	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T82	Ubiquitin carboxyl-terminal hydrolase 37	DEG_APCC_KENBOX_2	220:224	PKEND	APC,CDC20,FZR1	0.9138	More...
Q9NWQ8	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	DEG_APCC_KENBOX_2	412:416	PKEND	APC,CDC20,FZR1	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons