DegronMD

Uniprot ID: Q5T7N2

Source protein: LINE-1 type transposase domain-containing protein 1

Source gene: L1TD1

Class: DEG_APCC_KENBOX_2

Location: 18:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5159

ASA_SCORE: 133.36

COIL: 0.7546

CONS_SCORE: 0.292

DSS_SCORE: 0.3253

HELIX: 0.2576

FCONS_SCORE: 0.7078

RIG_SCORE: 0.7892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A16V	TCGA-AP-A1DK	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.2778
p.A16V	DO42033	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.2778
p.E20G	TCGA-G4-6588	COAD	TCGA	KKENI	DEG_APCC_KENBOX_2	0.7199
p.E20G	DO10140	COAD	ICGC	KKENI	DEG_APCC_KENBOX_2	0.7199
p.E20K	DO222875	MELA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.7022
p.R27S	SIDM00454	Rhabdomyosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.R27S	SIDM00200	Ewing's Sarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.R27S	SIDM01112	Osteosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.R27S	SIDM00493	Other Solid Cancers	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.R27S	SIDM01173	Rhabdomyosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.R27S	SIDM00641	Burkitt's Lymphoma	GDSC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.Q29L	ACH-000355	Lung Cancer	CCLE	KKENI	DEG_APCC_KENBOX_2	0.1389
p.R14T	ACH-000617	Ovarian Cancer	CCLE	KKENI	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_APCC_KENBOX_2	1030:1034	KKENI	APC,CDC20,FZR1	0.5608	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_APCC_KENBOX_2	18:22	KKENI	APC,CDC20,FZR1	0.5159	More...
O94952	F-box only protein 21	DEG_APCC_KENBOX_2	622:626	KKENI	APC,CDC20,FZR1	0.5939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons