DegronMD

Uniprot ID: O94952

Source protein: F-box only protein 21

Source gene: FBXO21

Class: DEG_APCC_KENBOX_2

Location: 622:626

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5939

ASA_SCORE: 127.6

COIL: 0.8286

CONS_SCORE: 0.3048

DSS_SCORE: 0.6495

HELIX: 0.1636

FCONS_SCORE: 0.9327

RIG_SCORE: 0.7794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D627A	TCGA-21-A5DI	LUSC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.3056
p.V615M	TCGA-99-8028	LUAD	TCGA	KKENI	DEG_APCC_KENBOX_2	0.1389
p.N625S	TCGA-AP-A1DV	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.7069
p.E624K	TCGA-BH-A0HP	BRCA	TCGA	KKENI	DEG_APCC_KENBOX_2	0.7022
p.E617K	DO1755	BRCA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.D620A	DO45455	LUSC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.2778
p.K615N	DO227579	ORCA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.1389
p.N618S	DO43186	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_APCC_KENBOX_2	1030:1034	KKENI	APC,CDC20,FZR1	0.5608	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_APCC_KENBOX_2	18:22	KKENI	APC,CDC20,FZR1	0.5159	More...
O94952	F-box only protein 21	DEG_APCC_KENBOX_2	622:626	KKENI	APC,CDC20,FZR1	0.5939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons