DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: DEG_APCC_KENBOX_2

Location: 1030:1034

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5608

ASA_SCORE: 120.12

COIL: 0.741

CONS_SCORE: 0.3294

DSS_SCORE: 0.7205

HELIX: 0.234

FCONS_SCORE: 1.0267

RIG_SCORE: 0.6706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1034T	TCGA-12-0657	GBM	TCGA	KKENI	DEG_APCC_KENBOX_2	0.5966
p.I1034T	DO13911	GBM	ICGC	KKENI	DEG_APCC_KENBOX_2	0.5966
p.D1024N	TCGA-37-3792	LUSC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.1667
p.D1024N	DO27192	LUSC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.1667
p.R1021Q	TCGA-AJ-A3EL	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.0833
p.R1021Q	TCGA-D1-A1NZ	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.0833
p.R1021Q	DO41542	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.0833
p.R1021Q	DO41536	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.0833
p.G1025E	TCGA-B5-A3FC	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	0.1944
p.G1025E	DO41871	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	0.1944
p.N1033S	TCGA-C8-A3M7	BRCA	TCGA	KKENI	DEG_APCC_KENBOX_2	0.7069
p.N1033S	DO44133	BRCA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.7069
p.P1037H	TCGA-DU-6392	LGG	TCGA	KKENI	DEG_APCC_KENBOX_2	0.25
p.P1037H	DO22237	LGG	ICGC	KKENI	DEG_APCC_KENBOX_2	0.25
p.N1023I	TCGA-MH-A55W	KIRP	TCGA	KKENI	DEG_APCC_KENBOX_2	0.1389
p.N1023I	DO48516	KIRP	ICGC	KKENI	DEG_APCC_KENBOX_2	0.1389
p.K1022N	DO224732	BRCA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.2222
p.E1032G	DO222834	BTCA	ICGC	KKENI	DEG_APCC_KENBOX_2	0.7199
p.T1032I	SUIT-2	pancreas	COSMIC	KKENI	DEG_APCC_KENBOX_2	0.7078
p.S1044Y	CAL-72	bone	COSMIC	KKENI	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_APCC_KENBOX_2	1030:1034	KKENI	APC,CDC20,FZR1	0.5608	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_APCC_KENBOX_2	18:22	KKENI	APC,CDC20,FZR1	0.5159	More...
O94952	F-box only protein 21	DEG_APCC_KENBOX_2	622:626	KKENI	APC,CDC20,FZR1	0.5939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons