DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: LIG_APCC_ABBA_1

Location: 1956:1961

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6836

ASA_SCORE: 85.4833

COIL: 0.7848

CONS_SCORE: 0.8875

DSS_SCORE: 0.7896

HELIX: 0.0975

FCONS_SCORE: 1.0666

RIG_SCORE: 0.6843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1952A	TCGA-75-6214	LUAD	TCGA	LNIYED	LIG_APCC_ABBA_1	0.2222
p.D1969H	TCGA-C5-A902	CESC	TCGA	LNIYED	LIG_APCC_ABBA_1	0.1111
p.Y1959C	TCGA-CR-7383	HNSC	TCGA	LNIYED	LIG_APCC_ABBA_1	0.7087
p.N1967I	TCGA-D8-A1XK	BRCA	TCGA	LNIYED	LIG_APCC_ABBA_1	0.1667
p.T1967P	HT-115	large_intestine	COSMIC	LNIYED	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEV8	Exophilin-5	LIG_APCC_ABBA_1	1956:1961	LNIYED	APC,CDC20,FZR1	0.6836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons