DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_APCC_DBOX_1

Location: 364:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 83.1889

COIL: 0.7442

CONS_SCORE: 1

DSS_SCORE: 0.6437

HELIX: 0.1487

FCONS_SCORE: 1.1471

RIG_SCORE: 0.6689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S369L	TCGA-A5-A0G1	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	0.6556
p.S369L	Daoy	central_nervous_system	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	0.6556
p.D381Y	TCGA-AP-A1DV	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	0.0833
p.R365I	TCGA-BS-A0UV	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	0.8102
p.R365I	SIDM01588	Endometrial Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	0.8102
p.R365I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	0.8102
p.S379C	TCGA-K4-A54R	BLCA	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	0.1389
p.S379F	TCGA-XF-A9T6	BLCA	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	0.1389
p.R355I	DO2401	BRCA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.0833
p.P362H	DO233731	GACA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.7222
p.T371K	DO228971	LICA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.7306
p.S374R	DO229031	LICA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.2778
p.E359V	DO231518	LINC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.1944
p.M375I	DO37782	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.25
p.G380C	DO37480	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.1111
p.Q368H	DO37961	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.7582
p.E358D	DO40884	UCEC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.1667
p.E359Q	DO43033	UCEC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	0.1944
p.R382M	SIDM02021	Esophageal Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	0.0556
p.S362T	SIDM00122	Breast Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	0.7222
p.S362T	ACH-000288	Breast Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	0.7222
p.S362T	BT-549	breast	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	0.7222
p.S376L	SIDM00887	Other Solid Cancers	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	0.2222
p.S376L	ACH-000211	Brain Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	0.2222
p.S376L	Daoy	central_nervous_system	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	0.2222
p.S355T	BT-549	breast	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEV8	Exophilin-5	DEG_APCC_DBOX_1	364:372	KRTPLSSII	APC,CDC20,FZR1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRTPLSSII

Degron related mutations and impact score

Drug responses associated with EXPH5 mutations

All proteins holding degron of KRTPLSSII