DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_APCC_KENBOX_2

Location: 1181:1185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8051

ASA_SCORE: 117.42

COIL: 0.6584

CONS_SCORE: 0.5932

DSS_SCORE: 0.5406

HELIX: 0.3122

FCONS_SCORE: 1.0015

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1174Y	TCGA-AP-A1E0	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	0.1389
p.K1194T	TCGA-EY-A1GD	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	0.1944
p.K1185R	DO8264	COAD	ICGC	QKENF	DEG_APCC_KENBOX_2	0.7237
p.D1190H	DO23597	LUAD	ICGC	QKENF	DEG_APCC_KENBOX_2	0.1944
p.A1184G	DO231127	LUSC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.754
p.A1175D	DO46657	PAAD	ICGC	QKENF	DEG_APCC_KENBOX_2	0.1667
p.P1187H	DO51407	PRAD	ICGC	QKENF	DEG_APCC_KENBOX_2	0.2778
p.P1187H	DO42673	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.2778
p.E1177D	DO41133	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.3333
p.N1184H	SIDM00643	Non-Cancerous	GDSC	QKENF	DEG_APCC_KENBOX_2	0.7423
p.N1184H	ACH-002363	Non-Cancerous	CCLE	QKENF	DEG_APCC_KENBOX_2	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons