DegronMD

Uniprot ID: P52756

Source protein: RNA-binding protein 5

Source gene: RBM5

Class: DEG_APCC_KENBOX_2

Location: 554:558

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5123

ASA_SCORE: 95.04

COIL: 0.3962

CONS_SCORE: 0.3056

DSS_SCORE: 0.5316

HELIX: 0.5838

FCONS_SCORE: 1.003

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L551F	TCGA-A1-A0SI	BRCA	TCGA	QKENF	DEG_APCC_KENBOX_2	0.25
p.L551F	DO1774	BRCA	ICGC	QKENF	DEG_APCC_KENBOX_2	0.25
p.R546H	TCGA-AX-A1CE	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	0.1111
p.R546H	DO234171	ESAD	ICGC	QKENF	DEG_APCC_KENBOX_2	0.1111
p.R546H	DO42280	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.1111
p.S550I	TCGA-B5-A3FC	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	0.2222
p.S550I	DO41871	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.2222
p.S567F	TCGA-BF-A5ES	SKCM	TCGA	QKENF	DEG_APCC_KENBOX_2	0.0833
p.S567F	DO219456	SKCM	ICGC	QKENF	DEG_APCC_KENBOX_2	0.0833
p.K559E	TCGA-D3-A3ML	SKCM	TCGA	QKENF	DEG_APCC_KENBOX_2	0.3056
p.K559E	DO47413	SKCM	ICGC	QKENF	DEG_APCC_KENBOX_2	0.3056
p.L568F	TCGA-DR-A0ZM	CESC	TCGA	QKENF	DEG_APCC_KENBOX_2	0.0556
p.L568F	DO6254	CESC	ICGC	QKENF	DEG_APCC_KENBOX_2	0.0556
p.S561N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	QKENF	DEG_APCC_KENBOX_2	0.25
p.S561N	ACH-002256	Leukemia	CCLE	QKENF	DEG_APCC_KENBOX_2	0.25
p.S561N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	QKENF	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons