DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PKRTPLSS
Uniprot ID:
Q8NEV8
Source protein:
Exophilin-5
Source gene:
EXPH5
Class:
DEG_SCF_FBW7_1
Location:
363:370
E3 ligase:
FBXW7
DEGRON score:
0.9941
ASA_SCORE:
85.9
COIL:
0.8551
CONS_SCORE:
1
DSS_SCORE:
0.6422
HELIX:
0.0806
FCONS_SCORE:
1.1209
RIG_SCORE:
0.6493
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S369L
TCGA-A5-A0G1
UCEC
TCGA
PKRTPLSS
DEG_SCF_FBW7_1
0.6556
p.S369L
Daoy
central_nervous_system
COSMIC
PKRTPLSS
DEG_SCF_FBW7_1
0.6556
p.R365I
TCGA-BS-A0UV
UCEC
TCGA
PKRTPLSS
DEG_SCF_FBW7_1
0.6991
p.R365I
SIDM01588
Endometrial Carcinoma
GDSC
PKRTPLSS
DEG_SCF_FBW7_1
0.6991
p.R365I
ACH-000993
Endometrial/Uterine Cancer
CCLE
PKRTPLSS
DEG_SCF_FBW7_1
0.6991
p.S379C
TCGA-K4-A54R
BLCA
TCGA
PKRTPLSS
DEG_SCF_FBW7_1
0.0833
p.S379F
TCGA-XF-A9T6
BLCA
TCGA
PKRTPLSS
DEG_SCF_FBW7_1
0.0833
p.R355I
DO2401
BRCA
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.1111
p.P362H
DO233731
GACA
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.75
p.S374R
DO229031
LICA
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.2222
p.E359V
DO231518
LINC
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.2222
p.M375I
DO37782
SKCM
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.1944
p.G380C
DO37480
SKCM
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.0556
p.Q368H
DO37961
SKCM
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.7582
p.E358D
DO40884
UCEC
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.1944
p.E359Q
DO43033
UCEC
ICGC
PKRTPLSS
DEG_SCF_FBW7_1
0.2222
p.S362T
SIDM00122
Breast Carcinoma
GDSC
PKRTPLSS
DEG_SCF_FBW7_1
0.75
p.S362T
ACH-000288
Breast Cancer
CCLE
PKRTPLSS
DEG_SCF_FBW7_1
0.75
p.S362T
BT-549
breast
COSMIC
PKRTPLSS
DEG_SCF_FBW7_1
0.75
p.S376L
SIDM00887
Other Solid Cancers
GDSC
PKRTPLSS
DEG_SCF_FBW7_1
0.1667
p.S376L
ACH-000211
Brain Cancer
CCLE
PKRTPLSS
DEG_SCF_FBW7_1
0.1667
p.S376L
Daoy
central_nervous_system
COSMIC
PKRTPLSS
DEG_SCF_FBW7_1
0.1667
p.S355T
BT-549
breast
COSMIC
PKRTPLSS
DEG_SCF_FBW7_1
0.1111
Drug responses associated with EXPH5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKRTPLSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEV8
Exophilin-5
DEG_SCF_FBW7_1
363:370
PKRTPLSS
FBXW7
0.9941
More...