DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: LIG_APCC_ABBA_1

Location: 1800:1805

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8422

ASA_SCORE: 75.6833

COIL: 0.6833

CONS_SCORE: 0.7804

DSS_SCORE: 0.4698

HELIX: 0.2175

FCONS_SCORE: 0.8688

RIG_SCORE: 0.6918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1793H	TCGA-19-5956	GBM	TCGA	INVHGD	LIG_APCC_ABBA_1	0.1389
p.R1793H	SIDM00176	Chondrosarcoma	GDSC	INVHGD	LIG_APCC_ABBA_1	0.1389
p.R1793H	ACH-002094	Bone Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	0.1389
p.R1793H	CHSA8926	bone	COSMIC	INVHGD	LIG_APCC_ABBA_1	0.1389
p.H1790Q	TCGA-HT-7689	LGG	TCGA	INVHGD	LIG_APCC_ABBA_1	0.0556
p.D1805N	TCGA-W3-AA1R	SKCM	TCGA	INVHGD	LIG_APCC_ABBA_1	0.6932
p.D1805N	SIDM00534	Colorectal Carcinoma	GDSC	INVHGD	LIG_APCC_ABBA_1	0.6932
p.D1805N	SIDM01588	Endometrial Carcinoma	GDSC	INVHGD	LIG_APCC_ABBA_1	0.6932
p.D1805N	ACH-000986	Colon/Colorectal Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	0.6932
p.D1805N	ACH-000993	Endometrial/Uterine Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	0.6932
p.D1805N	HT-115	large_intestine	COSMIC	INVHGD	LIG_APCC_ABBA_1	0.6932
p.E1794G	DO42793	UCEC	ICGC	INVHGD	LIG_APCC_ABBA_1	0.1667
p.D1798N	HT-115	large_intestine	COSMIC	INVHGD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEV8	Exophilin-5	LIG_APCC_ABBA_1	1800:1805	INVHGD	APC,CDC20,FZR1	0.8422	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons