DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_SCF_FBW7_1

Location: 112:117

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 76.35

COIL: 0.87

CONS_SCORE: 0.6616

DSS_SCORE: 0.5599

HELIX: 0.0955

FCONS_SCORE: 0.7449

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V106I	TCGA-06-5416	GBM	TCGA	PTPFSS	DEG_SCF_FBW7_1	0.1667
p.R102K	TCGA-ER-A193	SKCM	TCGA	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.E114V	DO227990	COCA	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.7693
p.D103E	DO229032	LICA	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.0833
p.T127I	DO232224	PBCA	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.R113M	DO37851	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.8632
p.P108T	DO50278	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.2222
p.P108Q	DO47607	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	0.2222
p.S127F	SIDM01261	Breast Carcinoma	GDSC	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.S127F	SIDM00314	Breast Carcinoma	GDSC	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.S127F	ACH-000097	Breast Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.S127F	ACH-002208	Breast Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.S127F	YMB-1-E	breast	COSMIC	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.R118Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPFSS	DEG_SCF_FBW7_1	0.3056
p.R118Q	ACH-000795	Leukemia	CCLE	PTPFSS	DEG_SCF_FBW7_1	0.3056
p.R118Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTPFSS	DEG_SCF_FBW7_1	0.3056
p.R102S	ACH-001412	Bladder Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	0.0556
p.S120F	YMB-1-E	breast	COSMIC	PTPFSS	DEG_SCF_FBW7_1	0.25
p.R111Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTPFSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEV8	Exophilin-5	DEG_SCF_FBW7_1	112:117	PTPFSS	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons