DegronMD

Uniprot ID: Q6ZU65

Source protein: Ubinuclein-2

Source gene: UBN2

Class: DEG_SCF_FBW7_1

Location: 1081:1086

E3 ligase: FBXW7

DEGRON score: 0.9962

ASA_SCORE: 113.9667

COIL: 0.9807

CONS_SCORE: 0.3158

DSS_SCORE: 0.6778

HELIX: 0.007

FCONS_SCORE: 1.0494

RIG_SCORE: 0.5544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1079F	TCGA-DX-A8BP	SARC	TCGA	PTPKPT	DEG_SCF_FBW7_1	0.2778
p.S1079F	DO220056	SARC	ICGC	PTPKPT	DEG_SCF_FBW7_1	0.2778
p.P1081R	DO227999	COCA	ICGC	PTPKPT	DEG_SCF_FBW7_1	0.7512
p.A1096E	DO27883	ORCA	ICGC	PTPKPT	DEG_SCF_FBW7_1	0.0556
p.V1071A	SIDM00683	Prostate Carcinoma	GDSC	PTPKPT	DEG_SCF_FBW7_1	0.0556
p.V1071A	ACH-000977	lymph_node	CCLE	PTPKPT	DEG_SCF_FBW7_1	0.0556
p.V1071A	LNCaP-Clone-FGC	prostate	COSMIC	PTPKPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU65	Ubinuclein-2	DEG_SCF_FBW7_1	1081:1086	PTPKPT	FBXW7	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons