DegronMD

Uniprot ID: Q6ZU65

Source protein: Ubinuclein-2

Source gene: UBN2

Class: LIG_APCC_ABBAyCdc20_2

Location: 157:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6833

ASA_SCORE: 106.0286

COIL: 0.7594

CONS_SCORE: 0.3661

DSS_SCORE: 0.4065

HELIX: 0.1933

FCONS_SCORE: 0.7589

RIG_SCORE: 0.7532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H161Y	TCGA-14-1794	GBM	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H161Y	DO13024	GBM	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.6118
p.N167S	TCGA-B5-A0JR	UCEC	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N167S	DO41791	UCEC	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D168N	TCGA-EB-A553	SKCM	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D168N	DO47329	SKCM	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D164E	TCGA-MM-A84U	KIRC	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D164E	DO50653	KIRC	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E154K	DO7801	COAD	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.I160F	SIDM00628	Breast Carcinoma	GDSC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU65	Ubinuclein-2	LIG_APCC_ABBAyCdc20_2	157:163	KKLIHTE	APC,CDC20,FZR1	0.6833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons