DegronMD

Uniprot ID: Q13469

Source protein: Nuclear factor of activated T-cells, cytoplasmic 2

Source gene: NFATC2

Class: DEG_SCF_FBW7_2

Location: 113:120

E3 ligase: FBXW7

DEGRON score: 0.9735

ASA_SCORE: 53.425

COIL: 0.5594

CONS_SCORE: 0.4313

DSS_SCORE: 0.4025

HELIX: 0.095

FCONS_SCORE: 1.1636

RIG_SCORE: 0.7368

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q123H	TCGA-49-AAR9	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.25
p.Q123H	DO218921	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.25
p.Q123L	TCGA-49-AAR9	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.25
p.Q123L	DO218921	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.25
p.I122M	TCGA-69-7978	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.2778
p.I122M	DO24920	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2778
p.P117L	TCGA-90-A4ED	LUSC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.7582
p.P117L	DO45482	LUSC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.7582
p.P117A	TCGA-BH-A0B6	BRCA	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.7503
p.P117A	DO2641	BRCA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.7503
p.R112Q	TCGA-EO-A22R	UCEC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	0.3056
p.R112Q	DO233898	GACA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.3056
p.R112Q	DO42713	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.3056
p.D109N	DO49943	CESC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.R124H	DO16101	HNSC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.R124H	DO47849	STAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.R124H	DO42713	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.R124H	DO43971	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.T106N	DO229018	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.1389
p.A124E	DO229019	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.H125Q	DO229024	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.1944
p.H125Q	DO229034	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.1944
p.P127T	DO229008	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.1389
p.S107I	DO24349	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.6111
p.R124C	DO25262	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.R124C	23132-87	stomach	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.S107L	DO46597	OV	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.6111
p.D109A	DO229459	SKCA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.P110L	DO37515	SKCM	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.6944
p.P110L	DO221004	WT	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.6944
p.A115T	DO38404	STAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.7139
p.P128L	DO41235	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	0.1111
p.P111S	SIDM00270	Head and Neck Carcinoma	GDSC	IEITPSHE	DEG_SCF_FBW7_2	0.2778
p.P111S	ACH-002294	Head and Neck Cancer	CCLE	IEITPSHE	DEG_SCF_FBW7_2	0.2778
p.P111S	PCI-15A	upper_aerodigestive_tract	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.2778
p.R129C	SIDM00256	Neuroblastoma	GDSC	IEITPSHE	DEG_SCF_FBW7_2	0.0833
p.R129C	ACH-002281	Neuroblastoma	CCLE	IEITPSHE	DEG_SCF_FBW7_2	0.0833
p.R129C	NB14	autonomic_ganglia	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.0833
p.G124R	MCC13	skin	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.2222
p.P112S	HT-3	cervix	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.3056
p.R109C	NB14	autonomic_ganglia	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IEITPSHE

Degron related mutations and impact score

Drug responses associated with NFATC2 mutations

All proteins holding degron of IEITPSHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SCF_FBW7_2	113:120	IEITPSHE	FBXW7	0.9735	More...