DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: DEG_SCF_FBW7_1

Location: 1983:1989

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 92.0857

COIL: 0.9379

CONS_SCORE: 0.3811

DSS_SCORE: 0.4815

HELIX: 0.0297

FCONS_SCORE: 0.7445

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1979Q	TCGA-A5-A2K5	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.R1979Q	TCGA-ND-A4WC	UCS	TCGA	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.R1979Q	DO41379	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.R1979Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.R1979Q	ACH-000980	Lung Cancer	CCLE	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.R1979Q	NCI-H1155	lung	COSMIC	LMTPSDS	DEG_SCF_FBW7_1	0.2222
p.P1986L	TCGA-EO-A22U	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	0.7582
p.P1986L	DO43755	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	0.7582
p.T1985A	TCGA-FI-A2D5	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	0.825
p.T1985A	DO41331	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	0.825
p.T1985K	DO228971	LICA	ICGC	LMTPSDS	DEG_SCF_FBW7_1	0.8417
p.T1985K	DO229037	LICA	ICGC	LMTPSDS	DEG_SCF_FBW7_1	0.8417
p.C1990R	SIDM00217	Colorectal Carcinoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	0.3056
p.C1990R	SIDM00634	Ewing's Sarcoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31629	Transcription factor HIVEP2	DEG_SCF_FBW7_1	1983:1989	LMTPSDS	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons