DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: DEG_SCF_TRCP1_1

Location: 397:402

E3 ligase: BTRC

DEGRON score: 0.9874

ASA_SCORE: 77.2667

COIL: 0.6983

CONS_SCORE: 0.4306

DSS_SCORE: 0.6354

HELIX: 0.0437

FCONS_SCORE: 0.8477

RIG_SCORE: 0.6045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F401L	TCGA-AP-A0LM	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.587
p.F401L	TCGA-E6-A1LX	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.587
p.F401L	DO43306	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.587
p.F401L	DO41020	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.587
p.F401S	TCGA-DF-A2KU	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.6871
p.F401S	DO223286	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.6871
p.S398F	TCGA-DU-6392	LGG	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.7982
p.S398F	DO22237	LGG	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.7982
p.E408K	TCGA-UY-A9PE	BLCA	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.1667
p.E408K	DO219043	BLCA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.1667
p.H391Q	DO229006	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.1667
p.R403H	DO231165	LUSC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons