DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: DEG_SCF_TRCP1_1

Location: 672:677

E3 ligase: BTRC

DEGRON score: 0.9794

ASA_SCORE: 85.3167

COIL: 0.8033

CONS_SCORE: 0.3312

DSS_SCORE: 0.6319

HELIX: 0.055

FCONS_SCORE: 0.836

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L662F	TCGA-06-5416	GBM	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.0556
p.L662F	DO10880	GBM	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.0556
p.R678H	TCGA-55-A4DG	LUAD	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.3056
p.R678H	TCGA-CD-A4MG	STAD	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.3056
p.R678H	DO26337	LUAD	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.3056
p.R678H	DO48009	STAD	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.3056
p.T671M	TCGA-A5-A2K5	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.75
p.T671M	DO41379	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.75
p.T671M	ACH-002396	Bone Cancer	CCLE	DSGYFS	DEG_SCF_TRCP1_1	0.75
p.T671M	Sarc9371	bone	COSMIC	DSGYFS	DEG_SCF_TRCP1_1	0.75
p.D672N	TCGA-D3-A51T	SKCM	TCGA	DSGYFS	DEG_SCF_TRCP1_1	0.6932
p.D672N	DO47389	SKCM	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.6932
p.A682S	DO228948	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.1944
p.V686L	DO229027	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons